Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7407 |
| PDBID: | 6BSP |
| Chains: | AB_C |
| Organism: | Mus musculus, Human papillomavirus 16 |
| Method: | EM |
| Resolution (Å): | 4.70 |
| Reference: | 10.3390/v9120374 |
| Antibody | |
| Antibody: | H16.U4 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human papillomavirus (HPV) major capsid protein L1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >6BSP_A|Chain A|U4 Heavy chain|Mus musculus (10090) SGGGLVKPGGSLKLSCEASGFTFSSYAMSWVRQTPEKRLEWVASISSGGNTHYPDSVKGRFTISRDNARNILYLQMSSLRSEDTAMYYCARGLYYGYDEGSDFDYWGQG |
Light Chain: B
Mutation: NULL
| >6BSP_B|Chain B|U4 Light chain|Mus musculus (10090) DIVMSQSPSSLAVSVGEKVTMSCKSSQSLLYSNTQKNYLAWYQQKPGQSPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSVKAEDLAVYYCQQYYSYPLTFGAGTKL |
Antigen
Chain: C
Mutation: NULL
| >6BSP_C|Chain C, D, E, F, G, H|Major capsid protein L1|Human papillomavirus type 16 (333760) YLPPVPVSKVVSTDEYVARTNIYYHAGTSRLLAVGHPYFPIKKPNNNKILVPKVSGLQYRVFRIHLPDPNKFGFPDTSFYNPDTQRLVWACVGVEVGRGQPLGVGISGHPLLNKLDDTENASAYAANAGVDNRECISMDYKQTQLCLIGCKPPIGEHWGKGSPCTNVAVNPGDCPPLELINTVIQDGDMVDTGFGAMDFTTLQANKSEVPLDICTSICKYPDYIKMVSEPYGDSLFFYLRREQMFVRHLFNRAGAVGENVPDDLYIKGSGSTANLASSNYFPTPSGSMVTSDAQIFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMSLCAAISTSETTYKNTNFKEYLRHGEEYDLQFIFQLCKITLTADVMTYIHSMNSTILEDWNFGLQPPPGGTLEDTYRFVTSQAIACQKHTPPAPKEDPLKKYTFWEVNLKEKFSADLDQFPLGRKFLLQAGLKAKPKF |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: GLY15 GLY16 SER62 LYS64 GLY65 ARG66 THR68 ARG83 C: SER173 PRO174 CYS175 THR176 ASN177 ALA179 VAL180 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
