Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7406 |
| PDBID: | 6BSP |
| Chains: | AB_D |
| Organism: | Mus musculus, Human papillomavirus 16 |
| Method: | EM |
| Resolution (Å): | 4.70 |
| Reference: | 10.3390/v9120374 |
| Antibody | |
| Antibody: | H16.U4 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human papillomavirus (HPV) major capsid protein L1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >6BSP_A|Chain A|U4 Heavy chain|Mus musculus (10090) SGGGLVKPGGSLKLSCEASGFTFSSYAMSWVRQTPEKRLEWVASISSGGNTHYPDSVKGRFTISRDNARNILYLQMSSLRSEDTAMYYCARGLYYGYDEGSDFDYWGQG |
Light Chain: B
Mutation: NULL
| >6BSP_B|Chain B|U4 Light chain|Mus musculus (10090) DIVMSQSPSSLAVSVGEKVTMSCKSSQSLLYSNTQKNYLAWYQQKPGQSPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSVKAEDLAVYYCQQYYSYPLTFGAGTKL |
Antigen
Chain: D
Mutation: NULL
| >6BSP_D|Chain C, D, E, F, G, H|Major capsid protein L1|Human papillomavirus type 16 (333760) YLPPVPVSKVVSTDEYVARTNIYYHAGTSRLLAVGHPYFPIKKPNNNKILVPKVSGLQYRVFRIHLPDPNKFGFPDTSFYNPDTQRLVWACVGVEVGRGQPLGVGISGHPLLNKLDDTENASAYAANAGVDNRECISMDYKQTQLCLIGCKPPIGEHWGKGSPCTNVAVNPGDCPPLELINTVIQDGDMVDTGFGAMDFTTLQANKSEVPLDICTSICKYPDYIKMVSEPYGDSLFFYLRREQMFVRHLFNRAGAVGENVPDDLYIKGSGSTANLASSNYFPTPSGSMVTSDAQIFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMSLCAAISTSETTYKNTNFKEYLRHGEEYDLQFIFQLCKITLTADVMTYIHSMNSTILEDWNFGLQPPPGGTLEDTYRFVTSQAIACQKHTPPAPKEDPLKKYTFWEVNLKEKFSADLDQFPLGRKFLLQAGLKAKPKF |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: TYR98 B: LYS18 SER52 THR53 ARG54 ASP60 THR63 SER65 THR74 D: PRO410 LEU414 GLU415 ALA427 CYS428 GLN429 HIS431 PRO434 LYS437 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
