Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7319 |
| PDBID: | 7P2D |
| Chains: | C_A |
| Organism: | Homo sapiens, Lama glama |
| Method: | XRD |
| Resolution (Å): | 3.20 |
| Reference: | 10.1016/j.jbc.2022.102168 |
| Antibody | |
| Antibody: | hCD11bNb1 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Integrin receptor αM |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: C
Mutation: NULL
| >7P2D_C|Chain C|hCD11bNb1 nanobody|Lama glama (9844) MQVQLVETGGGLVQAGGSLRLSCAASGNINSFNAMGWFRQAPGKQRELVAAITFGGRTNYADSVKGRFTISRDNTKGSVYLQMNSLKPEDTAVYYCAASENNLLTGVWHYWGRGTQVTVSSLEHHHHHH |
Antigen
Chain: A
Mutation: NULL
| >7P2D_A|Chain A|Isoform 2 of Integrin alpha-M|Homo sapiens (9606) FNLDTENAMTFQENARGFGQSVVQLQGSRVVVGAPQEIVAANQRGSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSLAATTSPPQLLACGPTVHQTCSENTYVKGLCFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQLKKSKTLFSLMQYSEEFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFRITNGARKNAFKILVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQELNTIASKPPRDHVFQVNNFEALKTIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAITSNGPLLSTVGSYDWAGGVFLYTSKEKSTFINMTRVDSDMNDAYLGYAAAIILRNRVQSLVLGAPRYQHIGLVAMFRQNTGMWESNANVKGTQIGAYFGASLCSVDVDSNGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGQRARWQCDAVLYGEQGQPWGRFGAALTVLGDVNGDKLTDVAIGAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLSPRLQYFGQSLSGGQDLTMDGLVDLTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAGEVRVCLHVQKSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKRSTRRQTQVLGLTQTCETLKLQLPNCIEDPVSPIVLRLNFSLVGTPLSAFGNLRPVLAEDAQRLFTALFPFEKNTGGLEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: MET1 ASN28 ILE29 ASN30 SER31 ASN33 THR53 PHE54 GLY55 ARG57 GLU100 ASN101 ASN102 LEU103 VAL107 A: LYS154 SER177 GLU178 GLU179 PHE180 ARG181 ILE182 HIS183 LEU198 LYS200 PRO201 ILE202 THR203 GLN204 LEU205 LEU206 GLY207 ARG208 HIS210 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
