Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7295 |
| PDBID: | 7NX0 |
| Chains: | D_C |
| Organism: | Homo sapiens, Lama glama |
| Method: | XRD |
| Resolution (Å): | 1.95 |
| Reference: | 10.1038/s41586-021-03959-5 |
| Antibody | |
| Antibody: | 3.16 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Leukocyte tyrosine kinase (LTK) |
| Antigen mutation: | No |
| Durg Target: | P29376 |
Sequence information
Antibody
Chain: D
Mutation: NULL
| >7NX0_D|Chain B[auth D], D[auth E]|Nb3.16|Lama glama (9844) QVQLQESGGGLVQTGGSLRLSCTASGRTFSSLAMGWFRQAPGKEREFVAAISWSTGITDYSDSVKGRFTMSRDNAKSTVYLQMNSLKPEDTAVYYCAAVDRHSPGSAWYNRNFGSWGQGTQVTVSS |
Antigen
Chain: C
Mutation: NULL
| >7NX0_C|Chain A[auth B], C|Leukocyte tyrosine kinase receptor|Homo sapiens (9606) GTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCLGESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGCSEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELFLQPLAVTENHGEVEIRRHGTDEVD |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: PHE37 GLU44 ARG45 GLU46 ASP100 HIS102 SER103 SER106 ALA107 TRP108 TYR109 ASN110 ARG111 ASN112 PHE113 GLY114 TRP116 C: THR98 GLY100 ALA101 ALA102 GLY103 GLN104 LEU105 VAL108 LEU110 TYR157 VAL220 ARG221 ALA222 GLY223 GLU224 LEU225 TRP277 THR278 LEU290 GLN291 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
