Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 729 |
| PDBID: | 4FQR |
| Chains: | cd_C |
| Organism: | Influenza A virus (A/Hong Kong/1/1968(H3N2)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 4.10 |
| Reference: | 10.1038/nature11414 |
| Antibody | |
| Antibody: | C05 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | P03437 |
Sequence information
Antibody
Heavy Chain: c
Mutation: NULL
| >4FQR_c|Chain AA[auth a], CA[auth c], EA[auth e], GA[auth g], IA[auth i], KA[auth k], MA[auth m], OA[auth o], QA[auth q], SA[auth s], UA[auth u], Y[auth w]|Broadly neutralizing antibody C05, heavy chain|Homo sapiens (9606) QVQLQESGGGLVQPGESLRLSCVGSGSSFGESTLSYYAVSWVRQAPGKGLEWLSIINAGGGDIDYADSVEGRFTISRDNSKETLYLQMTNLRVEDTGVYYCAKHMSMQQVVSAGWERADLVGDAFDVWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC |
Light Chain: d
Mutation: NULL
| >4FQR_d|Chain BA[auth b], DA[auth d], FA[auth f], HA[auth h], JA[auth j], LA[auth l], NA[auth n], PA[auth p], RA[auth r], TA[auth t], VA[auth v], Z[auth x]|Broadly neutralizing antibody C05, light chain|Homo sapiens (9606) DIQLTQSPSSLSASVGDRVTLTCQASQDIRKFLNWYQQKPGKGPKLLIYDASNLQRGVPSRFSGGGSGTDFTLIISSLQPEDVGTYYCQQYDGLPFTFGGGTKVVIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >4FQR_C|Chain A, C, E, G, I, K, M, O, Q, S, U, W|Hemagglutinin HA1 chain|Influenza A virus (506350) ADPGATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| c: PHE29 GLY30 GLU31 TYR36 MET105 SER106 MET107 VAL110 VAL111 SER112 ALA113 GLY114 TRP115 GLU116 ARG117 ALA118 d: TYR49 ARG56 C: TYR92 THR125 GLN126 ASN127 GLY128 GLY129 SER130 ASN131 SER139 TRP147 THR149 LYS150 GLY152 SER153 SER180 THR181 GLN183 GLU184 THR186 SER187 LEU188 GLY219 LEU220 SER221 SER222 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
