Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7287 |
| PDBID: | 7NOZ |
| Chains: | R_C |
| Organism: | Homo sapiens, Lama glama |
| Method: | XRD |
| Resolution (Å): | 3.90 |
| Reference: | 10.1002/pro.4432 |
| Antibody | |
| Antibody: | hFPNb1 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Properdin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: R
Mutation: NULL
| >7NOZ_R|Chain F[auth R]|hFPNb1 nanobody|Lama glama (9844) QVQLVESGGGLVQAGGSLRLSCAASERTFTIYAMGWFRQAPGKEREFVAAISRSGENTDYADSVKGRFTISRDNNKNTISLQMNSLKPEDTAVYYCAAGRAILVHTTKKEYDHWGQGTQVTVSS |
Antigen
Chain: C
Mutation: NULL
| >7NOZ_C|Chain C|Properdin|Homo sapiens (9606) DPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVC |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| R: ILE103 LEU104 THR107 C: THR34 GLY45 LEU46 LEU47 ASN59 PHE62 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
