Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7286 |
| PDBID: | 7NOZ |
| Chains: | R_D |
| Organism: | Homo sapiens, Lama glama |
| Method: | XRD |
| Resolution (Å): | 3.90 |
| Reference: | 10.1002/pro.4432 |
| Antibody | |
| Antibody: | hFPNb1 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Properdin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: R
Mutation: NULL
| >7NOZ_R|Chain F[auth R]|hFPNb1 nanobody|Lama glama (9844) QVQLVESGGGLVQAGGSLRLSCAASERTFTIYAMGWFRQAPGKEREFVAAISRSGENTDYADSVKGRFTISRDNNKNTISLQMNSLKPEDTAVYYCAAGRAILVHTTKKEYDHWGQGTQVTVSS |
Antigen
Chain: D
Mutation: NULL
| >7NOZ_D|Chain D|Properdin|Homo sapiens (9606) GVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPAC |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| R: ARG28 THR31 ILE32 ARG54 SER55 GLU57 ASN75 ASN76 ARG101 ALA102 ILE103 LEU104 VAL105 HIS106 D: SER267 PRO268 CYS269 PRO270 VAL271 THR272 LEU275 GLY276 GLN277 THR278 MET279 GLN281 ASN285 THR303 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
