Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7282 |
| PDBID: | 7NK4 |
| Chains: | F_A |
| Organism: | Influenza A virus (A/Brevig Mission/1/1918(H1N1)), Camelidae mixed library |
| Method: | EM |
| Resolution (Å): | 5.32 |
| Reference: | 10.1038/s41467-021-27950-w |
| Antibody | |
| Antibody: | 8203 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H1N1 polymerase acidic protein |
| Antigen mutation: | No |
| Durg Target: | P03433 |
Sequence information
Antibody
Chain: F
Mutation: NULL
| >7NK4_F|Chain F|Nanobody 8203|Camelidae mixed library (1579311) QVQLQESGGGLVQAGGSLRLSCAAPGRILTLSRYVMGWFRQAPGKEREFVAAISPGTTDTDYADSVKGRFTISRDNAKNTVYLEMSSLKPEDTAVYVCAAGAASSGTVYRVYGLYNYRGQGTQVTVSSHHHHHHEPEA |
Antigen
Chain: A
Mutation: NULL
| >7NK4_A|Chain A|Polymerase acidic protein|Influenza A virus (A/Brevig Mission/1/1918(H1N1)) (88776) MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINERGESIIVESGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEITGTMRRLADQSLPPNFSSLENFRAYVDGFEPNGYIEGKLSQMSKEVNARIEPFLKTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMRTFFGWKEPNVVKPHEKGINPNYLLAWKQVLAELQDIENEEKIPKTKNMKKTSQLKWALGENMAPEKVDFDDCKDVSDLKQYDSDEPELRSLASWIQSEFNKACELTDSSWIELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRSAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| F: VAL2 GLN3 TYR34 A: GLN7 CYS8 THR177 GLU181 SER184 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
