Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7258 |
| PDBID: | 7N9V |
| Chains: | H_K |
| Organism: | Human immunodeficiency virus 1, Lama glama |
| Method: | XRD |
| Resolution (Å): | 3.45 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | GYAR Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 capsid protein |
| Antigen mutation: | No |
| Durg Target: | Q72497; P12497; P35963; P03366; P04587; P03367; P03369; P04585; O93182; P12499; |
Sequence information
Antibody
Chain: H
Mutation: NULL
| >7N9V_H|Chain G[auth B], H[auth E], I[auth F], J[auth H], K[auth J], L|Nanobody-GYAR|Lama glama (9844) DVQLQESGGGLVQAGGSLRLSCAASGSISRFNAMGWWRQAPGKEREFVARIVKGGYAVLADSVKGRFTISIDSAENTLALQMNRLKPEDTAVYYCFAALDTAYWGQGTQVTVS |
Antigen
Chain: K
Mutation: NULL
| >7N9V_K|Chain A, B[auth C], C[auth D], D[auth G], E[auth I], F[auth K]|Capsid protein|Human immunodeficiency virus 1 (11676) PIVQNLQGQMVHQCISPRTLNAWVKVVEEKAFSPEVIPMFSALSCGATPQDLNTMLNTVGGHQAAMQMLKETINEEAAEWDRLHPVHAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTHNPPIPVGEIYKRWIILGLNKIVRMYSPTSILDIRQGPKEPFRDYVDRFYKTLRAEQASQEVKNAATETLLVQNANPDCKTILKALGPGATLEEMMTACQGVGP |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ASN32 ALA33 TRP37 PHE47 ARG50 VAL52 LYS53 GLY54 GLY55 TYR56 VAL58 PHE93 ALA95 LEU96 ASP97 THR98 ALA101 TRP103 K: ASP197 THR200 ILE201 LYS203 ALA204 LEU205 GLY206 PRO207 GLY208 ALA209 GLU212 GLU213 THR216 ALA217 GLN219 GLY220 VAL221 GLY222 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
