Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7250 |
| PDBID: | 7N65 |
| Chains: | GH_E |
| Organism: | Human immunodeficiency virus 1, Homo sapiens |
| Method: | EM |
| Resolution (Å): | 4.15 |
| Reference: | 10.7554/eLife.68110 |
| Antibody | |
| Antibody: | QA013.2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 BG505 SOSIP gp120 |
| Antigen mutation: | No |
| Durg Target: | P00750 |
Sequence information
Antibody
Heavy Chain: G
Mutation: NULL
| >7N65_G|Chain C, G, K|Fab QA013.2 Heavy Chain, variable region|Homo sapiens (9606) DIRIAESGGGLVQPGESLRLACEIIELGFRRAWTTWVRQAPGKGLEWVADINEDGSEKKYGPSVTGRFTISRDNGKNLVFLQMNSLRVEDTATYYCAREAYHLVYDDRIPRGNWFDPWGPGTLVTVSS |
Light Chain: H
Mutation: NULL
| >7N65_H|Chain D, H, L|Fab QA013.2 Light Chain, , variable region|Homo sapiens (9606) QSVLTQPPSVSGAPGQRVVISCTGSRSNIGAGYDVHWYQQSPGKVPRIIIYGSNSRSSGVPARFSGSKSGTSASLAITGLQAEDEADYYCQSYDTTLTASVFGGGTKV |
Antigen
Chain: E
Mutation: NULL
| >7N65_E|Chain A, E, I|Envelope glycoprotein gp41|Human immunodeficiency virus 1 (11676) MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARAENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| G: HIS102 LEU103 VAL104 TYR105 ASP106 ASP107 ARG108 E: ASN142 ASP146 ILE326 ILE327 GLY328 ASP329 ILE330 ARG331 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
