Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 725 |
| PDBID: | 4FP8 |
| Chains: | IM_B |
| Organism: | Influenza A virus (A/Hong Kong/1/1968(H3N2)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.95 |
| Reference: | 10.1038/nature11414 |
| Antibody | |
| Antibody: | C05 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | P03437 |
Sequence information
Antibody
Heavy Chain: I
Mutation: NULL
| >4FP8_I|Chain E[auth H], G[auth I], I[auth J], K|Antibody C05, heavy chain|Homo sapiens (9606) QVQLQESGGGLVQPGESLRLSCVGSGSSFGESTLSYYAVSWVRQAPGKGLEWLSIINAGGGDIDYADSVEGRFTISRDNSKETLYLQMTNLRVEDTGVYYCAKHMSMQQVVSAGWERADLVGDAFDVWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC |
Light Chain: M
Mutation: NULL
| >4FP8_M|Chain F[auth L], H[auth M], J[auth N], L[auth O]|Antibody C05, light chain|Homo sapiens (9606) DIQLTQSPSSLSASVGDRVTLTCQASQDIRKFLNWYQQKPGKGPKLLIYDASNLQRGVPSRFSGGGSGTDFTLIISSLQPEDVGTYYCQQYDGLPFTFGGGTKVVIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: B
Mutation: NULL
| >4FP8_B|Chain A, B, C, D|Hemagglutinin HA1 chain|Influenza A virus (506350) ADPGVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| I: TYR31 MET96 SER97 MET98 M: ARG56 B: TYR98 THR131 GLN132 ASN133 GLY134 GLY135 SER136 ASN137 SER145 TRP153 THR155 LYS156 SER157 GLY158 SER159 HIS183 SER186 THR187 GLN189 GLU190 THR192 SER193 LEU194 LEU226 SER227 SER228 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
