Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7215 |
| PDBID: | 7MFG |
| Chains: | HL_A |
| Organism: | Influenza A virus, Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.87 |
| Reference: | 10.1038/s41591-021-01636-8 |
| Antibody | |
| Antibody: | 30-1D06 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 H1N1 hemagglutinin HA1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7MFG_H|Chain C[auth E], G[auth H], K[auth J]|310-030-1D06 Heavy|Homo sapiens (9606) QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYGISWVRQAPGQGLEWMGGIIGMFGTTNYAQKFQGRVTITADEFTSTAYMELSSLRSEDTAVYYCARGGSYYVDYFHHWGQGTLVTVSS |
Light Chain: L
Mutation: NULL
| >7MFG_L|Chain D[auth F], H[auth K], L|310-030-1D06 Light|Homo sapiens (9606) EIVLTQSPGTLSLFSGERATLSCRASQSVSSSSLAWYQQKHGQGPRLIMYGASSRATGIPDRFSGSGFGTDFTITISRLEPEDFAVYYCQQYGSSSGTFGQGTKLEMK |
Antigen
Chain: A
Mutation: NULL
| >7MFG_A|Chain A, E[auth C], I[auth G]|Hemagglutinin HA1 chain|Influenza A virus (11320) DTICIGYHANNSTDTVDTVCEKNVTVTHSVNLLEDSHNGKLCLLKGIAPLQLGNCSVAGWILGNPECELLISKESWSYIVETPNPENGTCYPGYFADYEELREQLSSVSSFERFEIFPKESSWPNHTVTGVSASCSHNGKSSFYRNLLWLTGKNGLYPNLSKSYVNNKEKEVLVLWGVHHPPNIGNQRALYHTENAYVSVVSSHYSRRFTPEIAKRPKVRDQEGRINYYWTLLEPGDTIIFEANGNLIAPWYAFALSRGFGSGIITSNAPMDECDAKCQTPQGAINSSLPFQNVHPVTIGECPKYVRSAKLRMVTGLRNIPSIQSR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: PHE29 MET53 PHE54 PHE74 THR75 A: HIS18 HIS38 VAL40 ASN41 LEU42 SER291 LEU292 PRO293 THR318 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
