Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7213 |
| PDBID: | 7MFG |
| Chains: | JK_I |
| Organism: | Influenza A virus, Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.87 |
| Reference: | 10.1038/s41591-021-01636-8 |
| Antibody | |
| Antibody: | 30-1D06 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 H1N1 hemagglutinin HA2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: J
Mutation: NULL
| >7MFG_J|Chain C[auth E], G[auth H], K[auth J]|310-030-1D06 Heavy|Homo sapiens (9606) QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYGISWVRQAPGQGLEWMGGIIGMFGTTNYAQKFQGRVTITADEFTSTAYMELSSLRSEDTAVYYCARGGSYYVDYFHHWGQGTLVTVSS |
Light Chain: K
Mutation: NULL
| >7MFG_K|Chain D[auth F], H[auth K], L|310-030-1D06 Light|Homo sapiens (9606) EIVLTQSPGTLSLFSGERATLSCRASQSVSSSSLAWYQQKHGQGPRLIMYGASSRATGIPDRFSGSGFGTDFTITISRLEPEDFAVYYCQQYGSSSGTFGQGTKLEMK |
Antigen
Chain: I
Mutation: NULL
| >7MFG_I|Chain B, F[auth D], J[auth I]|Hemagglutinin HA2 chain|Influenza A virus (11320) GLFGAIAGFIEGGWTGMVDGWYGYHHQNEQGSGYAADQKSTQNAINCITNKVNSVIEKMNTQFTAVGKEFNKLERRMENLNKKVDDGFLDIWTYNAELLVLLENERTLDFHDSNVKNLYEKVKSQLKNNAKEIGNGCFEFYHKCNNECMESVKNGTYDYPKYSEESKLNREKIDGVSGRLVPRGSPGSGYIPEAPRDGQAYVRKDGEWVLLSTFLGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| J: THR28 PHE29 SER30 SER31 TYR32 MET53 PHE54 THR56 PHE74 GLY96 SER97 TYR98 TYR99 K: SER94 I: VAL18 ASP19 GLY20 TRP21 ALA36 GLN38 THR41 GLN42 ILE45 ASN46 ILE48 THR49 VAL52 ASN53 ILE56 GLU57 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
