Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7189 |
| PDBID: | 5OMM |
| Chains: | C_B |
| Organism: | Norovirus GII.10, Vicugna pacos |
| Method: | XRD |
| Resolution (Å): | 1.70 |
| Reference: | 10.1371/journal.ppat.1006636 |
| Antibody | |
| Antibody: | Nano-14 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Norovirus capsid protein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: C
Mutation: NULL
| >5OMM_C|Chain C|Nanobody (VHH) Nano-14|Vicugna pacos (30538) QVQLQESGGGLVQSGGSLRLSCAASRNINSMHVVGWYRQAPGNQRELVASITDDGSTDYVDSVKGRFTISRDIAENTVYLQMNSLNPEDTAVYYCKGTIVVFTTPMHYWGKGTQVTVSS |
Antigen
Chain: B
Mutation: NULL
| >5OMM_B|Chain A, B|Capsid protein|Norovirus GII.10 (747305) SKPFTLPILTLGELTNSRFPLPIDVLYTNPNESAIVQCQNGRCTLDGELQGTTQLLPTGICAFRGKVTQQVQDEHRGTHWNMTVTNLNGTPFDPTEDVPAPLGTPDFSGQIYGVISQRNTNTVPGEGNLPANRAHEAVIATYSPKFTPKLGNIQFSTWETQDVSSGQPTKFTPVGLASVDANSHFDQWTLPSYSGALTLNMNLAPSVAPVFPGECLLFFRSFIPLKGGYGNPAIDCLMPQEWVQHLYQESAPSLSDVALVRYVNPETGRTLFEAKLHRNGFLTVARNSAGPVVAPTNGYFRFDSWVNQFYTLAPM |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: GLN1 MET106 HIS107 TRP109 GLY110 B: ALA357 HIS358 GLU359 TRP381 GLU382 THR383 GLN384 ASP385 LYS449 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
