Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7188 |
| PDBID: | 5OMM |
| Chains: | C_A |
| Organism: | Norovirus GII.10, Vicugna pacos |
| Method: | XRD |
| Resolution (Å): | 1.70 |
| Reference: | 10.1371/journal.ppat.1006636 |
| Antibody | |
| Antibody: | Nano-14 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Norovirus capsid protein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: C
Mutation: NULL
| >5OMM_C|Chain C|Nanobody (VHH) Nano-14|Vicugna pacos (30538) QVQLQESGGGLVQSGGSLRLSCAASRNINSMHVVGWYRQAPGNQRELVASITDDGSTDYVDSVKGRFTISRDIAENTVYLQMNSLNPEDTAVYYCKGTIVVFTTPMHYWGKGTQVTVSS |
Antigen
Chain: A
Mutation: NULL
| >5OMM_A|Chain A, B|Capsid protein|Norovirus GII.10 (747305) SKPFTLPILTLGELTNSRFPLPIDVLYTNPNESAIVQCQNGRCTLDGELQGTTQLLPTGICAFRGKVTQQVQDEHRGTHWNMTVTNLNGTPFDPTEDVPAPLGTPDFSGQIYGVISQRNTNTVPGEGNLPANRAHEAVIATYSPKFTPKLGNIQFSTWETQDVSSGQPTKFTPVGLASVDANSHFDQWTLPSYSGALTLNMNLAPSVAPVFPGECLLFFRSFIPLKGGYGNPAIDCLMPQEWVQHLYQESAPSLSDVALVRYVNPETGRTLFEAKLHRNGFLTVARNSAGPVVAPTNGYFRFDSWVNQFYTLAPM |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: GLN1 SER25 HIS32 ASP53 ASP54 ILE99 VAL100 VAL101 PHE102 THR103 THR104 PRO105 MET106 TYR108 A: HIS298 ARG299 GLY300 GLN333 ALA357 HIS358 GLU359 VAL361 ALA363 TYR365 SER379 THR380 TRP381 GLU382 THR383 GLN384 ALA400 SER401 ASP403 ASN405 LYS449 GLY450 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
