Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7166 |
| PDBID: | 5O0W |
| Chains: | F_B |
| Organism: | Trypanosoma congolense IL3000, Vicugna pacos |
| Method: | XRD |
| Resolution (Å): | 2.57 |
| Reference: | 10.1371/journal.pntd.0005932 |
| Antibody | |
| Antibody: | 474 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Fructose-1,6-bisphosphate aldolase (ALD) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: F
Mutation: NULL
| >5O0W_F|Chain E, F, G, H|Nb474|Vicugna pacos (30538) QVQLQESGGGLVQPGGSLRLSCAASETALTYYAIGWFRQAPGKEREGVSCISRINSGSGARTDYADSVKGRFTISRDDAKNTVTLQMNSLEPEDTARYYCALDTTDRYDSANGRYYCTISSDTYDYWGQGTQVTVSSHHHHHH |
Antigen
Chain: B
Mutation: NULL
| >5O0W_B|Chain A, B, C, D|Fructose-bisphosphate aldolase|Trypanosoma congolense (strain IL3000) (1068625) MSRRVEVLLTQLPAYNRLKTPYEEELIETAKKMTAPGKGLLAADESTGSCSKRFAGIGLSNTAEHRRQYRALMLECAGFEQYISGVILHDETVYQRASTGETFPQLLRRRGVVPGIKTDCGLEPLVEGADGEQMTAGLDGYVKRAKKYYAVGCRFCKWRNVYKIQNGTVSEAVVRFNAETLARYAVLSQLCGLVPIVEPEVMIDGTHDIETCQRVSQHVWAEVVSALHRHGVVWEGCLLKPNMVVPGAESGQTATAEQVAEYTVKTLARVLPPALPGVTFLSGGLSEVMASEYLNAMNNSPLPRPWKLTFSYARALQSSAIKAWGGKSSGVAAGRRAFMHRAKMNSLAQLGRYNRGDDDKDSQSLYVAGNTYENLYFQSGGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| F: VAL2 GLU26 THR27 ALA28 TYR31 TYR32 ARG53 ASP103 THR104 THR105 ASP106 TYR108 ASP109 SER110 TYR115 ASP122 THR123 TYR124 ASP125 TYR126 B: LYS38 GLU75 CYS76 ALA77 GLY78 GLU80 GLN81 TYR82 SER98 THR99 GLY100 GLU101 ARG109 ARG110 ALA332 ARG335 ARG336 MET339 LYS343 LEU347 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
