Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7142 |
| PDBID: | 5KVE |
| Chains: | L_E |
| Organism: | Zika virus, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 1.70 |
| Reference: | 10.1016/j.cell.2016.07.020 |
| Antibody | |
| Antibody: | ZV-48 scFv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | ZIKA envelope DIII |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: L
Mutation: NULL
| >5KVE_L|Chain B[auth L]|ZV-48 Antibody scFv|Mus musculus (10090) MDIVMSQSPSSLAVSVGEKITMSCKSSQSLLYSNNEKNYLAWYQQKPGQSPKLLIYWASARDSGVPDRFTGSGSGTDFTLTISSVKAEDLAVFYCQQYYSYPYTFGGGTKLEIKGGGGSGGGGSGGGGSQVQLQQPGAELLKPGASVKLSCKASGYSFSNYWMHWVKQRPGQGPEWIGMIHPNSGNTKYNEKFKNKATLTVDKSSSMVYMQLSSLTSEDSAVFYCARLGNDMDYWGQGTSVTVSS |
Antigen
Chain: E
Mutation: NULL
| >5KVE_E|Chain A[auth E]|Genome polyprotein|Zika virus (64320) MRLKGVSYSLCTAAFTFTKIPAETLHGTVTVEVQYAGTDGPCKVPAQMAVDMQTLTPVGRLITANPVITESTENSKMMLELDPPFGDSYIVIGVGEKKITHHWHRSGSTI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: TYR31 SER32 ASN33 ASN34 GLU35 LYS36 TYR38 TRP56 TYR97 TYR98 SER99 TYR100 TYR102 ASN159 TYR160 TRP161 HIS163 MET178 HIS180 SER183 ASN185 LYS187 ARG226 LEU227 GLY228 ASN229 ASP230 MET231 E: TYR305 SER306 LEU307 LYS340 PRO342 ALA343 GLN344 VAL347 ASP348 GLN350 THR351 LEU352 THR353 PRO354 VAL355 GLY356 ARG357 LEU358 ASP384 TYR386 VAL391 GLY392 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
