Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 712 |
| PDBID: | 4DTG |
| Chains: | HL_K |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.80 |
| Reference: | 10.1182/blood-2012-01-401620 |
| Antibody | |
| Antibody: | 2021 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Concizumab(Approved) |
| Antigen | |
| Antigen: | Tissue factor pathway inhibitor |
| Antigen mutation: | No |
| Durg Target: | P10646 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4DTG_H|Chain B[auth H]|Humanized recombinant FAB fragment, FAB 2021, of a murine antibody, heavy chain|Homo sapiens (9606) EVQLVESGGGLVKPGGSLRLSCAASGFTFSNYAMSWVRQTPEKRLEWVATISRSGSYSYFPDSVQGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARLGGYDEGDAMDSWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESK |
Light Chain: L
Mutation: NULL
| >4DTG_L|Chain A[auth L]|Humanized recombinant FAB fragment, FAB 2021, of a murine antibody, light chain|Homo sapiens (9606) DIVMTQTPLSLSVTPGQPASISCKSSQSLLESDGKTYLNWYLQKPGQSPQLLIYLVSILDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCLQATHFPQTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: K
Mutation: NULL
| >4DTG_K|Chain C[auth K]|Tissue factor pathway inhibitor|Homo sapiens (9606) QEKPDFCFLEEDPGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICEDGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition L: GLU31 SER32 ASP33 LYS35 TYR37 ALA96 THR97 HIS98 PHE99 H: SER30 ASN31 ALA33 SER52 ARG53 SER54 TYR57 SER58 TYR59 PHE60 ASP62 GLN65 GLY101 TYR102 ASP103 ASP106 K: GLU10 GLU11 ASP12 PRO13 ARG17 TYR19 THR21 TYR23 PHE24 ASN26 GLN28 GLN31 CYS32 GLU33 ARG34 PHE35 LYS36 ASN43 GLU48 THR49 LEU50 GLU51 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
