Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7107 |
| PDBID: | 5FUU |
| Chains: | MN_F |
| Organism: | Human immunodeficiency virus 1, Homo sapiens |
| Method: | EM |
| Resolution (Å): | 4.19 |
| Reference: | 10.1126/science.aad2450 |
| Antibody | |
| Antibody: | PGT151 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 JR-FL gp120 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: M
Mutation: NULL
| >5FUU_M|Chain G[auth H], I[auth M]|IMMUNOGLOBULIN G PGT151|HOMO SAPIENS (9606) RVQLVESGGGVVQPGKSVRLSCVVSDFPFSKYPMYWVRQAPGKGLEWVAAISGDAWHVVYSNSVQGRFLVSRDNVKNTLYLEMNSLKIEDTAVYRCARMFQESGPPRLDRWSGRNYYYYSGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: N
Mutation: NULL
| >5FUU_N|Chain H[auth L], J[auth N]|IMMUNOGLOBULIN G PGT151|HOMO SAPIENS (9606) DIVMTQTPLSLSVTPGQPASISCKSSESLRQSNGKTSLYWYRQKPGQSPQLLVFEVSNRFSGVSDRFVGSGSGTDFTLRISRVEAEDVGFYYCMQSKDFPLTFGGGTKVDLKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: F
Mutation: NULL
| >5FUU_F|Chain B, D, F|HIV-1 ENVELOPE GLYCOPROTEIN GP160|HUMAN IMMUNODEFICIENCY VIRUS 1 (11676) AVGIGAVFLGFLGAAGSTMGAASMTLTVQARLLLSGIVQQQNNLLRAIEAQQRMLQLTVWGIKQLQARVLAVERYLGDQQLLGIWGCSGKLICTTAVPWNASWSNKSLDRIWNNMTWMEWEREIDNYTSEIYTLIEESQNQQEKNEQELLELD |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| M: TRP56 HIS57 ARG107 LEU108 ASP109 ARG110 TRP111 SER112 ARG114 ASN115 TYR116 TYR117 TYR118 TYR119 N: GLN31 SER32 ASN33 GLY34 SER96 LYS97 ASP98 PHE99 LEU101 F: ALA1 VAL2 GLY3 ILE4 GLY5 ALA6 VAL7 PHE8 LEU9 GLY10 PHE11 VAL28 ARG31 LEU32 SER35 GLY36 VAL38 GLN39 GLN41 ASN43 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
