Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7105 |
| PDBID: | 5F3J |
| Chains: | C_A |
| Organism: | Plasmodium vivax Sal-1, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 4.00 |
| Reference: | 10.1073/pnas.1600488113 |
| Antibody | |
| Antibody: | 2D10 scFv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Duffy binding protein (DBP) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: C
Mutation: NULL
| >5F3J_C|Chain C, D|Antibody 2D10 single chain variable fragment|Mus musculus (10090) MGILPSPGMPALLSLVSLLSVLLMGCVAETGLAAQPAMADIVITQDELSNPVTSGESVSISCRSSKSLLYQDGKTYLNWFLQRPGQSPQLLIYLMSTRASGVSDRFSGSGSGTDFTLEISRVEAEDVGVYYCQQLVEYPLTFGAGTKLELKRADGGGGSGGGGSGGGGSQVQLQQSGPELVKPGASVKISCKASGYAFISSWMNWVKQRPGKGLEWIGRIYPGDGDTHYNGKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYFCAREETAQTGGFDYWGQGTTLTVSSEASGADHGTKHHHHHH |
Antigen
Chain: A
Mutation: NULL
| >5F3J_A|Chain A, B|Duffy receptor|Plasmodium vivax (strain Salvador I) (126793) ASNTVMKNCNYKRKRRERDWDCNTKKDVCIPDRRYQLCMKELTNLVNNTDTNFHRDITFRKLYLKRKLIYDAAVEGDLLLKLNNYRYNKDFCKDIRWSLGDFGDIIMGTDMEGIGYSKVVENNLRSIFGTDEKAQQRRKQWWNESKAQIWTAMMYSVKKRLKGNFIWICKLNVAVNIEPQIYRWIREWGRDYVSELPTEVQKLKEKCDGKINYTDKKVCKVPPCQNACKSYDQWITRKKNQWDVLSNKFISVKNAEKVQTAGIVTPYDILKQELDEFNEVAFENEINKRDGAYIELCVCSVEEAKKNTQEVVTNVDN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: TYR70 GLN71 ASP72 LYS74 TYR76 LEU135 VAL136 GLU137 TYR138 LEU140 SER200 TRP202 ARG219 TYR221 ASP224 ASP226 HIS228 GLU268 GLU269 THR270 ALA271 GLY274 A: GLU413 LYS414 ASP416 LYS425 LYS428 VAL429 PRO430 PRO431 GLN433 ASN434 LYS437 SER438 ASP440 GLN441 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
