Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 710 |
| PDBID: | 4D3C |
| Chains: | HL_A |
| Organism: | Homo sapiens, Oryctolagus cuniculus |
| Method: | XRD |
| Resolution (Å): | 2.62 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | SFN68 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HEPATOCYTE GROWTH FACTOR |
| Antigen mutation: | No |
| Durg Target: | P14210 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4D3C_H|Chain B[auth H]|SFN68 FAB|ORYCTOLAGUS CUNICULUS (9986) QQQLVESGGRLVNPGESLTLTCKASGFTFSTYYMSWVRQAPGKGLEWIGYIGTSSGTTYYANSVKGRFTISSDNAQNTVFLQMTSLTDSDTATYFCARGLGRINLWGPGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKY |
Light Chain: L
Mutation: NULL
| >4D3C_L|Chain C[auth L]|SFN68 FAB|ORYCTOLAGUS CUNICULUS (9986) ELDLTQTPSSVSAAVGGTVTINCQASQSVSNLLAWYQQKPGQPPKLLIYGASNLESGVPSRFRGSGSGTEFTLTISGMKAEDAATYYCQSGYYSAGATFGAGTNVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >4D3C_A|Chain A|HEPATOCYTE GROWTH FACTOR|HOMO SAPIENS (9606) MGSSHHHHHHSQDPQRKRRNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGGSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: THR28 SER30 THR31 TYR32 TYR33 GLY52 SER54 SER55 THR57 GLY99 LEU100 GLY101 ARG102 L: ASN31 LEU32 TYR49 GLY50 ASN53 SER56 GLY91 TYR92 TYR93 A: MET155 ILE156 PRO157 HIS158 GLU159 HIS160 SER161 PHE162 LEU163 SER166 TYR167 ARG181 TRP188 PHE190 PRO194 GLU195 ARG197 TYR198 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
