Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7097 |
| PDBID: | 5DWU |
| Chains: | HL_B |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.97 |
| Reference: | 10.1080/19420862.2015.1119352 |
| Antibody | |
| Antibody: | CSL311 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Trabikibart(Phase-I) |
| Antigen | |
| Antigen: | Cytokine common receptor |
| Antigen mutation: | Yes |
| Durg Target: | P32927 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >5DWU_H|Chain C[auth H]|Fab - Heavy Chain|Homo sapiens (9606) EVQLLESGGGLVQPGGSLRLSCAASGFTFPWYRVHWVRQAPGKGLEWVSSIRSSGGFPYYNYKVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARFYDSFFDIWGQGTMVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPP |
Light Chain: L
Mutation: NULL
| >5DWU_L|Chain D[auth L]|Fab - Light Chain|Homo sapiens (9606) DIQMTQSPSSVSASVGDRVTITCRASQGISSWLAWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANSFPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: B
Mutation: N106Q
| >5DWU_B|Chain B|Cytokine receptor common subunit beta|Homo sapiens (9606) DEAQPQNLECFFDGAAVLSCSWEVRKEVASSVSFGLFYKPSPDAGEEECSPVLREGLGSLHTRHHCQIPVPDPATHGQYIVSVQPRRAEKHIKSSVNIQMAPPSLQVTKDGDSYSLRWETMKMRYEHIDHTFEIQYRKDTATWKDSKTETLQNAHSMALPALEPSTRYWARVRVRTSRTGYNGIWSEWSEARSWDTESVLPMW |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: PRO30 TRP31 TYR32 PHE99 TYR100 ASP101 PHE103 L: SER30 SER31 TRP32 TYR49 B: SER335 ARG364 TYR365 GLU366 HIS367 THR419 GLY420 TYR421 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
