Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7096 |
| PDBID: | 5DWU |
| Chains: | HL_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.97 |
| Reference: | 10.1080/19420862.2015.1119352 |
| Antibody | |
| Antibody: | CSL311 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Trabikibart(Phase-I) |
| Antigen | |
| Antigen: | Cytokine common receptor |
| Antigen mutation: | No |
| Durg Target: | P32927 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >5DWU_H|Chain C[auth H]|Fab - Heavy Chain|Homo sapiens (9606) EVQLLESGGGLVQPGGSLRLSCAASGFTFPWYRVHWVRQAPGKGLEWVSSIRSSGGFPYYNYKVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARFYDSFFDIWGQGTMVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPP |
Light Chain: L
Mutation: NULL
| >5DWU_L|Chain D[auth L]|Fab - Light Chain|Homo sapiens (9606) DIQMTQSPSSVSASVGDRVTITCRASQGISSWLAWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANSFPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >5DWU_A|Chain A|Cytokine receptor common subunit beta|Homo sapiens (9606) WERSLAGAEETIPLQTLRCYNDYTSHITCRWADTQDAQRLVNVTLIRRVNEDLLEPVSCDLSDDMPWSACPHPRCVPRRCVIPCQSFVVTDVDYFSFQPDRPLGTRLTVTLTQHVQPPEPRDLQISTDQDHFLLTWSVALGSPQSHWLSPGDLEFEVVYKRLQDSWEDAAILLSNTSQATLGPEHLMPSSTYVARVRTRLAPGSRLSGRPSKWSPEVCWDSQPG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: PRO30 TRP31 ARG33 ARG52 SER53 SER54 GLY55 GLY56 PHE57 PRO58 ASN74 PHE99 ASP101 SER102 L: TRP32 ALA91 ASN92 SER93 PHE94 ILE96 A: TYR39 ARG64 VAL65 ASN66 GLN101 SER102 PHE103 VAL104 VAL105 THR106 ASP107 VAL108 ASP109 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
