Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7076 |
| PDBID: | 5C3L |
| Chains: | D_B |
| Organism: | Xenopus laevis, Camelus dromedarius |
| Method: | XRD |
| Resolution (Å): | 2.90 |
| Reference: | 10.1126/science.aac7420 |
| Antibody | |
| Antibody: | 15 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Nucleoporin Nup58 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: D
Mutation: NULL
| >5C3L_D|Chain D|Nanobody Nb15|Camelus dromedarius (9838) AGTASQVQLQESGGGLVQPGGSLRLSCAASGFTFSNYAMSWVRQAPGKGLEVVSDIGSGGDRITYADSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCANQYGRGPGTQVTVSSGS |
Antigen
Chain: B
Mutation: NULL
| >5C3L_B|Chain B|Nucleoporin Nup58|Xenopus laevis (8355) AGTRPEDSKALKDENLPQLLCQDVENFQKFVKEQKQVQEEISRMSSKAMLKVQEDIKALKQLLSVASSGLQRNALAIDKLKIETAEELKNAEIALRTQKTPPGLQHENTAPADYFHTLVQQFEVQLQQYRQQIEELENHLAT |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: ASN31 TYR32 ALA33 MET34 SER35 VAL37 LEU45 VAL47 ASP50 ILE51 GLY52 SER53 ARG57 THR59 ALA97 ASN98 GLN99 TYR100 GLY101 ARG102 B: LEU353 GLU357 LEU360 ARG361 THR362 GLN363 LYS364 THR365 PRO366 PRO367 GLY368 LEU369 GLN370 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
