Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7055 |
| PDBID: | 4XT1 |
| Chains: | C_A |
| Organism: | Cytomegalovirus, Homo sapiens, Vicugna pacos |
| Method: | XRD |
| Resolution (Å): | 2.89 |
| Reference: | 10.1126/science.aaa5026 |
| Antibody | |
| Antibody: | 7 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | G-protein coupled receptor homolog US28 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: C
Mutation: NULL
| >4XT1_C|Chain C|nanobody 7|Vicugna pacos (30538) GPGSQVQLVESGGGLVRPGGSLRLSCAASGSIFTIYAMGWYRQAPGKQRELVARITFGGDTNYADSVKGRFTISRDNAKNAVYLQMNSLKPEDTAVYYCNAEETIVEEADYWGQGTQVTVSSRAAAHHHHHHHH |
Antigen
Chain: A
Mutation: NULL
| >4XT1_A|Chain A|G-protein coupled receptor homolog US28|Cytomegalovirus (10358) DYKDDDDAMTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKKDNQCMTDYDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQSRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFRQRLFSRDVSWYHSMSFSRRSSPSRRETSSDTLSDEVCRVSQIIP |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: GLN1 VAL2 GLN3 GLY26 SER27 ILE28 PHE29 THR30 ILE31 TYR32 ARG50 THR52 PHE53 GLY54 ASP56 ASN73 ALA74 GLU99 THR100 ILE101 VAL102 GLU103 GLU104 ASP106 TYR107 TRP108 A: GLN65 CYS66 ASP69 PHE72 ARG129 ALA132 ILE133 MET136 TYR138 ARG139 PRO140 VAL141 LYS142 ILE211 ILE214 VAL215 VAL217 SER218 GLN219 SER220 ARG221 HIS222 ARG225 ILE226 VAL229 LEU230 TYR291 VAL294 GLY295 THR296 LYS297 PHE298 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
