Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7032 |
| PDBID: | 4RRP |
| Chains: | GA_M |
| Organism: | Homo sapiens, Saccharomyces cerevisiae AWRI796 |
| Method: | XRD |
| Resolution (Å): | 2.79 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | 4RRP Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Antigen Asf4p |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: G
Mutation: NULL
| >4RRP_G|Chain B[auth G], D[auth H], F[auth I], H[auth J], J[auth K], L|Fab antibody, heavy chain|Homo sapiens (9606) EISEVQLVESGGGLVQPGGSLRLSCAASGFNVSYSSIHWVRQAPGKGLEWVAYIYPSSGYTSYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARSYSTKLAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTSRHHHHHH |
Light Chain: A
Mutation: NULL
| >4RRP_A|Chain A, C[auth B], E[auth C], G[auth D], I[auth E], K[auth F]|Fab antibody, light chain|Homo sapiens (9606) MSDIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQSQWYPITFGQGTKVEIKRTVAAPSVFIFPPSDSQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: M
Mutation: NULL
| >4RRP_M|Chain M, N, O, P, Q, R|Antigen Asf1p|Saccharomyces cerevisiae (764097) GSSIVSLLGIKVLNNPAKFTDPYEFEITFECLESLKHDLEWKLTYVGSSRSLDHDQELDSILVGPVPVGVNKFVFSADPPSAELIPASELVSVTVILLSCSYDGREFVRVGYYVNNEYDEEELRENPPAKVQVDHIVRNILAEKPRVTRFNIVWDNENEG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ASP1 GLN27 SER28 SER30 THR69 SER91 GLN92 TRP93 TYR94 G: SER30 TYR31 SER32 TYR50 SER53 SER54 TYR56 THR57 SER58 TYR96 SER97 LYS99 M: ILE9 LYS10 VAL11 LEU12 ASN13 ASN14 PRO15 ALA16 LYS17 ASP20 PRO21 GLU23 GLU25 PHE28 ILE60 LEU61 VAL62 GLY63 PRO64 PRO66 ASN70 LYS71 PHE72 VAL73 SER75 ASP77 ASP118 VAL136 ALA141 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
