Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7009 |
| PDBID: | 4OQT |
| Chains: | HL_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.23 |
| Reference: | 10.1124/jpet.113.211771 |
| Antibody | |
| Antibody: | Li81 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Opicinumab(Phase-II) |
| Antigen | |
| Antigen: | Leucine-rich repeat and Ig-containing Nogo receptor interacting protein-1 (LINGO-1) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4OQT_H|Chain C[auth H]|Heavy Chain of Li81 Fab, VH3-23|Homo sapiens (9606) EVQLLESGGGLVQPGGSLRLSCAASGFTFSAYEMKWVRQAPGKGLEWVSVIGPSGGFTFYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCATEGDNDAFDIWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL |
Light Chain: L
Mutation: NULL
| >4OQT_L|Chain B[auth L]|Light Chain of Li81 Fab, kappa 3|Homo sapiens (9606) DIQMTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPMYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >4OQT_A|Chain A|Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1|Homo sapiens (9606) TGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSY |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: SER28 SER30 SER31 TYR32 ASP50 ARG91 SER92 ASN93 TRP94 TYR97 H: ALA31 TYR32 GLU33 GLY52 PRO53 SER54 GLY56 PHE57 GLU99 ASN102 ASP103 ALA104 A: LEU97 ASP121 TYR122 GLN125 ARG146 SER149 GLY150 ASN152 GLU170 HIS174 HIS176 LYS197 ARG198 TYR200 ARG201 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
