Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6995 |
| PDBID: | 4NM8 |
| Chains: | IM_D |
| Organism: | Influenza A virus (A/Hong Kong/1/1968(H3N2)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 4.00 |
| Reference: | 10.1073/pnas.1319058110 |
| Antibody | |
| Antibody: | CR8043 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin HA2 |
| Antigen mutation: | No |
| Durg Target: | P03437 |
Sequence information
Antibody
Heavy Chain: I
Mutation: NULL
| >4NM8_I|Chain H, J[auth I], L[auth J]|Antibody CR8043, Heavy Chain|Homo sapiens (9606) QVQLVQSGAEVKKPGASVKLSCKASGYTFTAYSMHWVRQAPGQSLEWLGWINTAIGNTQYSQKFQDRVTITRDTSARTSYMELSSLRSGDTAVYFCARGASWDARGWSGYWGKGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCHHHHHH |
Light Chain: M
Mutation: NULL
| >4NM8_M|Chain G[auth L], I[auth M], K[auth N]|Antibody CR8043, Light Chain|Homo sapiens (9606) DIQMTQSPDSLAVSLGERATINCKSSQSVFSSSTNKNYLAWYQQKPGQPPKVLIYWSSTRESGVPDRFSASGSGTDFTLTISSLQAADVAVYYCHQYYTAPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: D
Mutation: NULL
| >4NM8_D|Chain B, D, F|Hemagglutinin HA2 Chain|Influenza A virus (strain A/Hong Kong/1/1968 H3N2) (506350) GLFGAIAGFIENGWEGMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTGRQLRENAEDMGNGCFKIYHKCDNACIESIRNGTYDHDVYRDEALNNRFQIKGV |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| M: SER27 THR28 ASN29 LYS30 TYR32 TRP50 I: THR28 ALA31 TYR32 ILE54 ASN56 ALA96 SER97 TRP98 ASP99 D: GLU15 GLY16 ILE18 ASP19 GLY20 ARG25 GLN27 GLY31 THR32 GLY33 GLN34 ALA36 LEU38 GLN42 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
