Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 698 |
| PDBID: | 4AQ1 |
| Chains: | D_C |
| Organism: | Geobacillus stearothermophilus, Lama glama |
| Method: | XRD |
| Resolution (Å): | 2.42 |
| Reference: | 10.1038/nature11155 |
| Antibody | |
| Antibody: | NBKB6 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SBSB PROTEIN |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: D
Mutation: NULL
| >4AQ1_D|Chain B, D|NBKB6|LAMA GLAMA (9844) QVQLQESGGGLVQAGGSLRLSCAASGRTSSAYAMGWFRQAPGKEREFVAGISSKGGSTYYGASMKGRFTISRDNAKNTVYLQMNGLAPEDTAVYYCAASDKYNFDTSHAGYGYWGQGTQVTVSSHHHHHH |
Antigen
Chain: C
Mutation: NULL
| >4AQ1_C|Chain C|SBSB PROTEIN|GEOBACILLUS STEAROTHERMOPHILUS (1422) MASFTDVAPQYKDAIDFLVSTGATKGKTETKFGVYDEITRLDAAVILARVLKLDVGNAKDAGFTDVPKDRAKYVNALVEAGVLNGKAPGKFGAYDPLTRVEMAKIIANAHKLKADDVKLPFTDVNDTWAPYVKALYKYEVTKGKTPTSFGAYQNITRGDFAQFVYRAVNINAVPEIVEVTAVNSTTVKVTFNTQIADVDFTNFAIDNGLTVTKATLSRDKKSVEVVVNKPFTRNQEYTITATGIKNLKGETAKELTGKFVWSVQDAVTVALNNSSLKVGEESGLTVKDQDGKDVVGAKVELTSSNTNIVVVSSGEVSVSAAKVTAVKPGTADVTAKVTLPDGVVLTNTFKVTVTEVPVQVQNQGFTLVDNLTNAPQNTVAFNKAEKVTSMFAGETKTVAMYDTKNGDPETKPVDFKDATVRSLNPIIATAAINGSELLVTANAGQSGKASFEVTFKDNTKRTFTVDVKKEPVLQDIKVDATSVKLSDEAVGGGEVEGVNQKTIKVSAVDQYGKEIKFGTKGKVTVTTNTEGLVIKNVNSDNTIDFDSGNSATDQFVVVATKDKIVNGKVEVKYFKNASDTTPTSTKTITVNVVNVKADATPVGLDIVAPSEIDVNAPNTASTADVDFINFESVEIYTLDSNGNRLKKVTPTATTLVGTNDYVEVNGNVLQFKGNDELTLLTSSSTVNVDVTADGITKRIPVKYINSASVPASATVATSPVTVKLNSSDNDLTFEELIFGVIDPTQLVKDEDINEFIAVSKAAKNDGYLYNKPLVTVKDASGEVIPTGANVYGLNHDATNGNIWFDEEQAGLAKKFSDVHFDVDFSLANVVKTGSGTVSSSPSLSDAIQLTNSGDAVSFTLVIKSIYVKGADKDDNNLLAAPVSVNVTVTKGS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: GLN39 PRO41 GLY42 LYS43 GLU44 ARG45 THR91 ALA92 VAL93 TYR95 GLN119 C: GLU524 THR557 ASN558 THR559 GLU560 GLY561 LEU562 VAL563 ILE564 LYS565 VAL567 SER569 ASN571 THR590 LYS593 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
