Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6974 |
| PDBID: | 4MXW |
| Chains: | HL_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.60 |
| Reference: | 10.1073/pnas.1310838110 |
| Antibody | |
| Antibody: | anti-LTα Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Pateclizumab(Phase-II) |
| Antigen | |
| Antigen: | Lymphotoxin α (LTα) |
| Antigen mutation: | No |
| Durg Target: | P01374 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4MXW_H|Chain I[auth H], J[auth W]|anti-Lymphotoxin alpha antibody heavy chain|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCAASGYTFTSYVIHWVRQAPGKGLEWVGYNNPYNAGTNYNEKFKGRFTISSDKSKNTAYLQMNSLRAEDTAVYYCSRPTMLPWFAYWGQGTLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK |
Light Chain: L
Mutation: NULL
| >4MXW_L|Chain K[auth L], L[auth V]|anti-Lymphotoxin alpha antibody light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQAVSSAVAWYQQKPGKAPKLLIYSASHRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQESYSTPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR |
Antigen
Chain: A
Mutation: NULL
| >4MXW_A|Chain B[auth A], E[auth X]|Lymphotoxin-alpha|Homo sapiens (9606) ADLGSDYKDDDDKKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPSTVFFGAFAL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: SER31 TYR32 VAL33 TYR50 ASN52 TYR54 ASN55 ALA56 GLY57 THR58 ASN59 PRO99 THR100 MET101 LEU102 PRO103 TRP104 L: GLN27 ALA28 SER30 SER31 ALA32 SER50 HIS53 SER91 TYR92 SER93 THR94 TRP96 A: LYS61 PRO63 ARG80 ALA81 ASN82 PHE87 LEU88 ASP90 GLY91 PHE92 SER93 LEU94 SER95 ASN96 LEU100 PRO102 THR103 SER104 PHE138 SER139 SER140 GLN141 THR176 GLN177 GLY178 ASP179 GLN180 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
