Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6973 |
| PDBID: | 4MXV |
| Chains: | YX_D |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.20 |
| Reference: | 10.1073/pnas.1310838110 |
| Antibody | |
| Antibody: | anti-LTα Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Pateclizumab(Phase-II) |
| Antigen | |
| Antigen: | Lymphotoxin α (LTα) |
| Antigen mutation: | No |
| Durg Target: | P01374 |
Sequence information
Antibody
Heavy Chain: Y
Mutation: NULL
| >4MXV_Y|Chain E[auth F], G[auth H], I[auth Y]|anti-Lymphotoxin alpha antibody heavy chain|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCAASGYTFTSYVIHWVRQAPGKGLEWVGYNNPYNAGTNYNEKFKGRFTISSDKSKNTAYLQMNSLRAEDTAVYYCSRPTMLPWFAYWGQGTLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK |
Light Chain: X
Mutation: NULL
| >4MXV_X|Chain D[auth E], F[auth L], H[auth X]|anti-Lymphotoxin alpha antibody light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQAVSSAVAWYQQKPGKAPKLLIYSASHRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQESYSTPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR |
Antigen
Chain: D
Mutation: NULL
| >4MXV_D|Chain A, B, C[auth D]|Lymphotoxin-alpha|Homo sapiens (9606) ADLGSDYKDDDDKKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPSTVFFGAFAL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| X: GLN27 ALA28 SER30 ALA32 TYR49 SER50 SER91 TYR92 SER93 THR94 TRP96 Y: SER31 TYR32 VAL33 TYR50 TYR53 ASN54 THR57 ASN58 TYR59 GLU61 PRO95 THR96 MET97 LEU98 PRO99 D: PRO29 ARG46 ALA47 ASN48 PHE53 LEU54 ASP56 GLY57 PHE58 SER59 LEU60 SER61 ASN62 LEU66 VAL67 PRO68 THR69 SER70 THR142 GLN143 GLY144 ASP145 GLN146 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
