Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 696 |
| PDBID: | 3X3F |
| Chains: | HL_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.10 |
| Reference: | 10.1038/srep17936 |
| Antibody | |
| Antibody: | KMTR2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Tumor necrosis factor receptor superfamily member 10B (DR5) |
| Antigen mutation: | No |
| Durg Target: | O14763 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >3X3F_H|Chain A[auth H]|Heavy chain of KMTR2|Homo sapiens (9606) QVQLVQSGAEMKKPGASVKVSCKTSGYTFTNYKINWVRQAPGQGLEWMGWMNPDTDSTGYPQKFQGRVTMTRNTSISTAYMELSSLRSEDTAVYYCARSYGSGSYYRDYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYG |
Light Chain: L
Mutation: NULL
| >3X3F_L|Chain B[auth L]|Light chain of KMTR2|Homo sapiens (9606) EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >3X3F_A|Chain C[auth A]|Tumor necrosis factor receptor superfamily member 10B|Homo sapiens (9606) ALITQQDLAPQQRVAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGSRADYKDDDDK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: LYS33 TRP50 ASN52 SER57 THR58 GLY59 TYR60 GLN65 GLY103 TYR106 ARG107 ASP108 L: GLU1 GLN27 SER28 SER30 TYR32 ARG91 SER92 ASN93 TRP94 LEU96 A: ILE87 GLU89 ASP90 GLY91 ARG92 ASP102 HIS106 ASP109 LEU110 LEU111 PHE112 CYS113 LEU114 ARG115 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
