Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6949 |
| PDBID: | 4LVO |
| Chains: | CB_A |
| Organism: | Plasmodium falciparum, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.26 |
| Reference: | 10.1038/ncomms4726 |
| Antibody | |
| Antibody: | NIMP.M7 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Subtilisin-like serine protease SUB1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >4LVO_C|Chain C|NIMP.M7 Fab heavy chain|Mus musculus (10090) QVQLQESGPDLVKPSSSLKLTCTTTGYSISSGYSWHWIRQEPGKSLEWMGYIHYSGSTDYNDSLKARITITRDTASNMFFLQLSSVTSDDTAVYYCVIYRYDGQWVFDDWGAGTTVTVSSAKTTPPSVFPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPGVLQSGLYTLSSSVTVPSSPWPSETVTCNVAHPASSTKVDKKIVPR |
Light Chain: B
Mutation: NULL
| >4LVO_B|Chain B|NIMP.M7 Fab light chain|Mus musculus (10090) DIVLTQSPATMSASLGQRVSMSCSASSSVSTSYFHWYQQKPGSSPKLWIYSTSNLASGVPGRFSGSGSGTSYSLSISSMEAEDAATYYCHQFHRSPLTFGAGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNR |
Antigen
Chain: A
Mutation: NULL
| >4LVO_A|Chain A|Subtilisin-like serine protease|Plasmodium falciparum (5833) SRPGKYHFNDEFRNLQWGLDLSRLDETQELINEHQVMSTRICVIDSGIDYNHPDLKDNIELNLKELHGRKGFDDDNNGIVDDIYGANFVNNSGNPMDDNYHGTHVSGIISAIGNNNIGVVGVDVNSKLIICKALDEHKLGRLGDMFKCLDYCISRNAHMINGSFSFDEYSGIFNSSVEYLQRKGILFFVSASNCSHPKSSTPDIRKCDLSINAKYPPILSTVYDNVISVANLKKNDNNNHYSLSINSFYSNKYCQLAAPGTNIYSTAPHNSYRKLNGTSMAAPHVAAIASLIFSINPDLSYKKVIQILKDSIVYLPSLKNMVAWAGYADINKAVNLAIKSKKTY |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: SER26 SER27 SER28 SER30 TYR33 THR70 PHE92 HIS93 ARG94 LEU97 C: TYR27 SER30 SER31 GLY32 TYR33 SER34 HIS36 TYR51 HIS53 TYR54 TYR99 ARG100 TYR101 ASP102 GLY103 TRP105 A: GLN362 VAL363 MET364 SER365 ARG367 GLU387 LEU388 LEU390 LYS391 GLU392 LEU393 HIS394 GLY395 ARG396 LYS397 ASP401 ASP402 ASP408 ILE410 LYS454 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
