Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6944 |
| PDBID: | 4LVH |
| Chains: | KL_J |
| Organism: | Influenza A virus (A/Korea/01/2009(H1N1)), Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.80 |
| Reference: | 10.1371/journal.pone.0089803 |
| Antibody | |
| Antibody: | 0587 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: K
Mutation: NULL
| >4LVH_K|Chain B, E, H, K|MONOCLONAL ANTIBODY H-CHAIN|Mus musculus (10090) VKLQQSGGGVVQPGGSLRLSCAASGFTFSDYDMSWIRQAPGKGLEWVSGILGGSERSYYRDSVKGRFTISRDNSRKTLYLQMNSLRAEDTAVYYCARHGSPGYTLYAWDYWGQGTMVTVSSASTKGPSVFPLAPSKSSTSGATAALGCLVKDYFPEPVTVSWNSGALTSSVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKSCAA |
Light Chain: L
Mutation: NULL
| >4LVH_L|Chain C, F, I, L|MONOCLONAL ANTIBODY L-CHAIN|Mus musculus (10090) DIQMTQSPASLAVSPGQRATITCRASESVSNYGINFINWFQQKPGQPPKLLIYTASNKGTGVPARFSGSGSGTDFTLTINPVEAEDTANYFCQQTKEVPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLDEYERHNSYTCEATHKTSTSPIVKSFN |
Antigen
Chain: J
Mutation: NULL
| >4LVH_J|Chain A, D, G, J|Hemagglutinin|Influenza A virus (644289) ADPGYLLEFDTLCIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDKHNGKLCKLRGVAPLHLGKCNIAGWILGNPECESLSTASSWSYIVETSSSDNGTCYPGDFIDYEELREQLSSVSSFERFEIFPKTSSWPNHDSNKGVTAACPHAGAKSFYKNLIWLVKKGNSYPKLSKSYINDKGKEVLVLWGIHHPSTSADQQSLYQNADAYVFVGSSRYSKKFKPEIAIRPKVRDQEGRMNYYWTLVEPGDKITFEATGNLVVPRYAFAMERNAGSGIIISDTPVHDCNTTCQTPKGAINTSLPFQNIHPITIGKCPKYVKSTKLRLATGLRNVPSIQSRGLFGAIAGFIEGGWTGMVDGWYGYHHQNEQGSGYAADLKSTQNAIDEITNKVNSVIEKMNTQFTAVGKEFNHLEKRIENLNKKVDDGFLDIWTYNAELLVLLENERTLDYHDSNVKNLYEKVRSQLKNNAKEIGNGCFEFYHKCDNTCMESVKNGTYDYPKYSEEAKLNREEIDGVRSLVPR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| K: GLY53 SER54 ARG56 SER57 TYR58 TYR59 ASP61 LYS64 TYR103 THR104 LEU105 L: GLU26 SER27 SER29 ASN30 TYR31 GLY32 ILE33 PHE35 LYS95 GLU96 VAL97 PRO98 TYR99 J: TRP60 GLU68 LEU70 SER71 THR72 ALA73 SER74 PHE111 GLU112 ARG113 PHE114 GLU115 ILE116 PRO118 LYS119 THR120 SER121 SER122 LYS146 SER162 LYS163 SER164 TYR165 ILE166 ASP168 LYS169 GLY170 LYS171 ARG252 TYR253 PHE255 ALA256 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
