Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6934 |
| PDBID: | 4L5F |
| Chains: | HL_E |
| Organism: | Mus musculus, dengue virus type 1 |
| Method: | XRD |
| Resolution (Å): | 2.45 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | DENV1-E106 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Dengue virus (DENV) type 1 envelope glycoprotein domain III |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4L5F_H|Chain A[auth H]|Heavy chain of E106 antibody (VH and CH1 of IgG2c)|Mus musculus (10090) EVQLQQSGPELVKPGASVKISCKASGYSFIGYYIHWVKQSPEKSLEWIGEINPRTGDTTYNQKFKAKATLTVDKSSSTAYMQLTSLTSEDSAVYYCTKRINWALDYWGQGTTLTVSSAKTTAPSVYPLAPVCGGTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPALLQSGLYTLSSSVTVTSNTWPSQTITCNVAHPASSTKVDKKIESRR |
Light Chain: L
Mutation: NULL
| >4L5F_L|Chain C[auth L]|Light chain of E106 antibody (kappa)|Mus musculus (10090) ETTVTQSPASLSVATGEKVTIRCITSTDIDDDMNWYQQKPGERPKLLISEGNTLRPGVPSRFSSSGYGTDFVFTIENTLSEDVADYFCLQSDNLPLTFGSGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNE |
Antigen
Chain: E
Mutation: NULL
| >4L5F_E|Chain B[auth E]|Envelope protein|Dengue virus 1 (11053) MASMTLKGMSYVMCTGSFKLEKEVAETQHGTVLVQVKYEGTDAPCKIPFSTQDEKGATQNGRLITANPIVTDKEKPVNIEAEPPFGESYIVVGAGEKALKLSWFKKGSSIG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ILE30 GLY31 TYR32 TYR33 GLU50 ARG53 THR54 ARG95 ILE96 ASN97 TRP98 L: ASP30 ASP31 ASP32 GLU50 GLY51 TYR67 SER91 ASP92 ASN93 LEU94 E: THR303 SER305 PHE306 LYS307 GLU309 LYS310 LYS325 TYR326 GLU327 GLY328 THR329 ASP330 ALA331 LYS361 GLU362 LYS385 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
