Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6933 |
| PDBID: | 4KVN |
| Chains: | HL_A |
| Organism: | Influenza A virus (A/Perth/16/2009(H3N2)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.10 |
| Reference: | 10.1016/j.chom.2013.06.004 |
| Antibody | |
| Antibody: | 39.29 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4KVN_H|Chain B[auth H]|Human IgG Heavy Chain|Homo sapiens (9606) VQLVESGGGVVQPGKSPRLSCAASGPTFSSYAVHWVRQAPGKGLEWVTLISYDGANQYYADSVKGRFTISRDNSKNTVYLQMNSLRPEDTAVYYCAVPGPVFGIFPPWSYFDNWGQGILVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: L
Mutation: NULL
| >4KVN_L|Chain C[auth L]|Human IgG Light Chain|Homo sapiens (9606) IVLTQSPATLSVSPGERATLSCRASQVISHNLAWYQQKPGQAPRLLIYGASTRASGIPARFSGSGSGTDYTLTITSLQPEDFAVYYCQHYSNWPPRLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >4KVN_A|Chain A|Hemagglutinin|Influenza A virus (654811) AGSTATLCLGHHAVPNGTIVKTITNDQIEVTNATELVQSSSTGEICDSPHQILDGKNCTLIDALLGDPQCDGFQNKKWDLFVERSKAYSNCYPYDVPDYASLRSLVASSGTLEFNNESFNWTGVTQNGTSSACIRRSKNSFFSRLNWLTHLNFKYPALNVTMPNNEQFDKLYIWGVHHPGTDKDQIFLYAQASGRITVSTKRSQQTVSPNIGSRPRVRNIPSRISIYWTIVKPGDILLINSTGNLIAPRGYFKIRSGKSSIMRSDAPIGKCNSECITPNGSIPNDKPFQNVNRITYGACPRYVKQNTLKLATGMRNVPEKQTRGIFGAIAGFIENGWEGMVDGWYGFRHQNSEGRGQAADLKSTQAAIDQINGKLNRLIGKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTKKQLRENAEDMGNGCFKIYHKCDNACIGSIRNGTYDHDVYRDEALNNRFQIKGSGRLVPR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: TYR53 ASP54 ALA56 VAL102 PHE103 GLY104 ILE105 PHE106 PRO107 PRO108 TRP109 L: SER30 HIS31 ASN32 GLY50 ALA51 SER52 THR53 ARG54 ALA60 ARG61 SER63 GLY64 SER65 GLY66 SER67 ASP70 THR76 SER77 GLN79 SER92 ASN93 TRP94 A: HIS34 VAL36 ASN54 SER70 LYS292 ASN294 PRO305 ASP307 THR334 VAL363 ASP364 GLY365 TRP366 GLN379 ALA380 LEU383 LYS384 THR386 GLN387 ILE390 ASP391 ILE393 ASN394 GLY395 LEU397 ASN398 ILE401 LYS403 THR404 ASN405 ARG498 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
