Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 692 |
| PDBID: | 3W9E |
| Chains: | AB_C |
| Organism: | Human herpesvirus 2 strain HG52, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.30 |
| Reference: | 10.1107/S0907444913016776 |
| Antibody | |
| Antibody: | E317 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | herpes simplex virus (HSV) Envelope glycoprotein D |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >3W9E_A|Chain B[auth A]|Antibody Fab heavy chain|Homo sapiens (9606) QVTLKQSGAEVKKPGSSVKVSCTASGGTLRTYGVSWVRQAPGQGLEWLGRTIPLFGKTDYAQKFQGRVTITADKSMDTSFMELTSLTSEDTAVYYCARDLTTLTSYNWWDLWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP |
Light Chain: B
Mutation: NULL
| >3W9E_B|Chain C[auth B]|Antibody Fab light chain|Homo sapiens (9606) EIVLTQSPGTLSLSPGERATLSCRASQSVTSSQLAWYQQKPGQAPRLLISGASNRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKLYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >3W9E_C|Chain A[auth C]|Envelope glycoprotein D|Human herpesvirus 2 (10315) MGRLTSGVGTAALLVVAVGLRVVCAKYALADPSLKMADPNRFRGKNLPVLDQLTDPPGVKRVYHIQPSLEDPFQPPSIPITVYYAVLERACRSVLLHAPSEAPQIVRGASDEARKHTYNLTIAWYRMGDNCAIPITVMEYTECPYNKSLGVCPIRTQPRWSYYDSFSAVSEDNLGFLMHAPAFETAGTYLRLVKINDWTEITQFILEHRARASCKYALPLRIPPAACLTSKAYQQGVTVDSIGMLPRFIPENQRTVALYSLKIAGWHGPKPPYTSTLLPPELSDTTNATQPELVPEDPEDHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: GLN1 GLY27 THR28 ARG30 THR31 TYR32 ILE52 LEU54 PHE55 LYS57 LYS74 SER75 MET76 ARG98 LEU100 THR101 THR102 LEU103 THR104 SER105 TYR106 ASN107 TRP108 ASP110 B: THR30 SER32 SER50 GLY51 ASN54 ARG55 ALA56 THR57 GLY58 TYR92 C: LEU25 ASP26 GLN27 LEU28 THR29 ASP30 LYS35 ARG36 TYR38 HIS39 GLN132 ARG134 TYR137 ASP139 SER140 LEU193 PRO194 ARG196 PRO198 ASP215 SER216 ILE217 GLY218 LEU220 PRO221 ARG222 PHE223 ILE224 ASN227 THR230 VAL231 TYR234 SER235 ILE238 ALA239 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
