Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6907 |
| PDBID: | 4KFZ |
| Chains: | C_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.80 |
| Reference: | 10.1038/srep03643 |
| Antibody | |
| Antibody: | anti-LMO2 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | LMO2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: C
Mutation: NULL
| >4KFZ_C|Chain C, D|Anti-LMO2 VH|Homo sapiens (9606) GGSMAEVQLLESGGGLVQPGGSLRLSCAASGFSFSHSPMNWVRQAPGKGLEWVSYISYNSSSIYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGLTESLELTADWFDYWGQGTLVTVSS |
Antigen
Chain: A
Mutation: NULL
| >4KFZ_A|Chain A, B|LMO-2|Homo sapiens (9606) SLDPSEEPVDEVLQIPPSLLTCGGCQQNIGDRYFLKAIDQYWHEDCLSCDLCGCRLGEVGRRLYYKLGRKLCRRDYLRLFGQDGLCASCDKRIRAYEMTMRVKDKVYHLECFKCAACQKHFCVGDRYLLINSDIVCEQDIYEWTKINGMI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition C: HIS31 ASN35 GLN39 PRO41 GLY42 LYS43 GLY44 LEU45 TRP47 TYR50 SER52 TYR53 ASN54 SER56 SER57 TYR59 TYR95 LEU100 THR101 GLU102 SER103 LEU104 GLU105 LEU106 THR107 ALA108 ASP109 TRP110 TRP114 GLY115 A: ASP53 SER56 CYS57 ASP58 LEU59 CYS60 GLY61 CYS62 ARG63 GLU66 CYS80 ARG81 ARG82 ASP83 ARG86 TYR104 GLU105 MET106 THR107 MET108 ARG109 VAL110 LYS111 VAL114 LEU117 PHE120 HIS128 PHE129 CYS130 VAL131 GLY132 ASP133 TYR135 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
