Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 69 |
| PDBID: | 1JRH |
| Chains: | HL_I |
| Organism: | Mus musculus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.80 |
| Reference: | 10.1006/jmbi.1997.1336 |
| Antibody | |
| Antibody: | A6 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | INTERFERON-GAMMA RECEPTOR ALPHA CHAIN |
| Antigen mutation: | No |
| Durg Target: | P15260 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >1JRH_H|Chain B[auth H]|ANTIBODY A6|Mus musculus (10090) AVKLQESGPGILKPSQTLSLTCSFSGFSLTTYGMGVGWIRQSSGKGLEWLAHIWWDDDKYYNPSLKSRLTISKDTSRNQVFLKITSVATADTATYYCARRAPFYGNHAMDYWGQGTTVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKI |
Light Chain: L
Mutation: NULL
| >1JRH_L|Chain A[auth L]|ANTIBODY A6|Mus musculus (10090) SVEMTQSPSSFSVSLGDRVTITCKASEDIYNRLAWYQQKPGNAPRLLISGATSLETEVPSRFSGSGSGKDYTLSITSLQTEDVATYYCQQYWSTWTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: I
Mutation: NULL
| >1JRH_I|Chain C[auth I]|INTERFERON-GAMMA RECEPTOR ALPHA CHAIN|Homo sapiens (9606) EMGTADLGPSSVPTPTNVTIESYNMNPIVYWEYQIMPQVPVFTVEVKNYGVKNSEWIDACINISHHYCNISDHVGDPSNSLWVRVKARVGQKESAYAKSEEFAVSRDG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: VAL2 GLU27 ASP28 TYR30 ARG32 LYS69 TYR91 TRP92 SER93 THR94 TRP96 H: TYR32 GLY33 TRP52 TRP53 ASP54 ASP56 TYR58 TYR59 PRO61 ARG95 TYR99 I: LYS47 TYR49 GLY50 VAL51 LYS52 ASN53 SER54 GLU55 TRP56 ASP76 SER78 SER80 TRP82 ARG84 LYS98 SER99 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
