Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 689 |
| PDBID: | 3VRL |
| Chains: | EF_D |
| Organism: | Mus musculus, Human immunodeficiency virus 1 |
| Method: | XRD |
| Resolution (Å): | 3.20 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | A10F9 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 capsid protein p24 |
| Antigen mutation: | No |
| Durg Target: | Q72497; O93182; P12497; P03369; P35963; P03367; P04587; P03366; P04585; P12499; |
Sequence information
Antibody
Heavy Chain: E
Mutation: NULL
| >3VRL_E|Chain A[auth E], D[auth H]|A10F9 Fab heavy chain|Mus musculus (10090) DVKLVESGGGLVKPGGSLKLSCAASGFTFSSYTMSWVRQTPEKRLEWVAIISSGGSYTYYSDSVKGRFTISRDNAKNTLYLQMSSLKSEDTAMYYCTRDEGNGNYVEAMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDC |
Light Chain: F
Mutation: NULL
| >3VRL_F|Chain B[auth F], E[auth L]|A10F9 Fab light chain|Mus musculus (10090) DIQMTQSPASLSASVGETVTITCRASGNIHNYLAWYQQKQGKSPQLLVYNAKTLADGVPSRFSGSGSGTQYSLKINSLQPEDFGSYYCQHFWSTPRTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: D
Mutation: NULL
| >3VRL_D|Chain C, F[auth D]|Gag protein|Human immunodeficiency virus 1 (11676) PIVQNLQGQMVHQPISPRTLNAWVKVIEEKGFSPEVIPMFTALSEGATPQDLNTMLNTVGGHQAAMQMLKDTINEEAAEWDRLHPVQAGPVAPGQMRDPRGSDIAGTTSTLQEQIGWMTHNPPIPVGDIYKRWIILGLNKIVRMYSPVSILDIKQGPKESFRDYVDRFFKTLRAEQCTQDVKNWMTDTLLVQNANPDCKTILRALGPGATLEEMMTACQGVGGPSHKARVL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| E: SER31 THR33 ILE50 ILE51 SER52 SER53 GLY54 GLY55 SER56 TYR57 THR58 TYR59 LYS65 THR69 ASP99 GLU100 GLY101 GLY103 ASN104 TYR105 VAL106 F: TYR32 PHE91 TRP92 SER93 THR94 PRO95 ARG96 D: GLN155 ASP187 VAL191 ASN195 ASP197 CYS198 THR200 ILE201 LEU202 ARG203 ALA204 LEU205 GLY206 PRO207 GLY208 ALA209 GLU213 MET214 THR216 ALA217 CYS218 GLN219 GLY220 VAL221 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
