Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6875 |
| PDBID: | 4I77 |
| Chains: | HL_Z |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.90 |
| Reference: | 10.1016/j.jmb.2013.01.024 |
| Antibody | |
| Antibody: | Lebrikizumab Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Lebrikizumab(Approved) |
| Antigen | |
| Antigen: | Cytokine interleukin 13 (IL-13) |
| Antigen mutation: | No |
| Durg Target: | P35225 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4I77_H|Chain A[auth H]|Lebrikizumab heavy chain|Homo sapiens (9606) QVTLRESGPALVKPTQTLTLTCTVSGFSLSAYSVNWIRQPPGKALEWLAMIWGDGKIVYNSALKSRLTISKDTSKNQVVLTMTNMDPVDTATYYCAGDGYYPYAMDNWGQGSLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESK |
Light Chain: L
Mutation: NULL
| >4I77_L|Chain B[auth L]|Lebrikizumab light chain|Homo sapiens (9606) DIVMTQSPDSLSVSLGERATINCRASKSVDSYGNSFMHWYQQKPGQPPKLLIYLASNLESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQNNEDPRTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: Z
Mutation: NULL
| >4I77_Z|Chain C[auth Z]|Interleukin-13|Homo sapiens (9606) GPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGRFN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: PHE27 SER30 ALA31 TYR32 SER33 TRP52 GLY53 ASP54 LYS56 ASP95 GLY96 TYR97 TYR98 PRO99 L: SER27 TYR28 ASN30 PHE32 TYR49 SER52 ASN53 ASN91 ASN92 Z: ALA9 GLU12 CYS29 ASN30 SER32 ILE52 ASN53 VAL54 SER55 GLY56 CYS57 SER58 ALA59 ILE60 GLU61 LYS62 GLN64 ARG65 MET66 SER68 GLY69 PRO72 LYS74 VAL75 SER76 ALA77 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
