Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6861 |
| PDBID: | 4HKZ |
| Chains: | BA_H |
| Organism: | Homo sapiens, Staphylococcus aureus subsp. aureus Mu50, Finegoldia magna |
| Method: | XRD |
| Resolution (Å): | 2.08 |
| Reference: | 10.1073/pnas.1307309110 |
| Antibody | |
| Antibody: | Trastuzumab Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Anbenitamab(Phase-II/III); Anvatabart(Phase-II/III); Cinrebafusp(Phase-II); Coprelotamab(Phase-III); Fidasimtamab(Phase-I); Runimotamab(Phase-I); Timigutuzumab(Phase-I); Trastuzumab(Approved); Zanidatamab(Preregistration); |
| Antigen | |
| Antigen: | Fab binding protein A |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >4HKZ_B|Chain B|Trastuzumab heavy chain|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK |
Light Chain: A
Mutation: NULL
| >4HKZ_A|Chain A|Trastuzumab light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE |
Antigen
Chain: H
Mutation: NULL
| >4HKZ_H|Chain C[auth H]|Immunoglobulin G-binding protein A|Staphylococcus aureus (158878) GSYNKDQQSAFYEILNMPNLNEAQRNGFIQSLKDDPSQSTNVLGEAKKLNESQA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: GLY15 GLY16 SER17 ARG19 THR58 TYR60 LYS65 GLY66 ARG67 THR69 ILE70 SER71 GLN82 ASN84 SER85 ARG87 H: ALA23 GLN24 GLY27 PHE28 GLN30 SER31 ASP34 ASP35 SER37 GLN38 ASN41 VAL42 GLU45 LEU49 GLN53 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
