Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6860 |
| PDBID: | 4HKX |
| Chains: | AB_E |
| Organism: | Influenza A virus (A/Solomon Islands/3/2006(H1N1)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.50 |
| Reference: | 10.1073/pnas.1218256109 |
| Antibody | |
| Antibody: | CH67 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin HA1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >4HKX_A|Chain B[auth A]|CH67 heavy chain|Homo sapiens (9606) QVQLVQSGAEVRKPGASVKVSCKASGYTFTDNYIHWVRQAPGQGLEWMGWIHPNSGATKYAQKFEGWVTMTRDTSISTVYMELSRSRSDDTAVYYCARAGLEPRSVDYYFYGLDVWGQGTAVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: B
Mutation: NULL
| >4HKX_B|Chain C[auth B]|CH67 light chain|Homo sapiens (9606) QSALTQPPSVSVAPGQTATITCGGNNIGRKRVDWFQQKPGQAPVLVVYEDSDRPSGIPERFSDSNSGTTATLTISRVEAGDEADYYCQVWDSDSDHVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: E
Mutation: NULL
| >4HKX_E|Chain A[auth E]|Hemagglutinin HA1|Influenza A virus (464623) ADPGYLLEAPLQLGNCSVAGWILGNPECELLISRESWSYIVEKPNPENGTCYPGHFADYEELREQLSSVSSFERFEIFPKESSWPNHTTTGVSASCSHNGESSFYKNLLWLTGKNGLYPNLSKSYANNKEKEVLVLWGVHHPPNIGDQRALYHTENAYVSVVSSHYSRKFTPEIAKRPKVRDQEGRINYYWTLLEPGDTIIFEANGNLIAPRYAFALSRG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition A: THR30 ASP31 TYR33 TRP50 HIS52 ASN54 SER55 LYS59 ARG104 SER105 VAL106 ASP107 TYR109 TYR111 B: ASN26 ARG29 TRP90 SER92 ASP93 ASP95 E: TYR95 THR131 GLY134 VAL135 SER136 ALA137 SER145 TRP153 THR155 GLY156 ASN158 GLY159 LEU160 ASN187 ILE188 GLY189 ASP190 ARG192 ALA193 LEU194 HIS196 LYS219 LYS222 ASP225 GLN226 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
