Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6848 |
| PDBID: | 4HG4 |
| Chains: | RS_E |
| Organism: | Influenza A virus (A/Japan/305+/1957(H2N2)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.20 |
| Reference: | 10.1038/nsmb.2500 |
| Antibody | |
| Antibody: | 2G1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H2N2 hemagglutinin HA1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: R
Mutation: NULL
| >4HG4_R|Chain AA[auth J], CA[auth L], EA[auth N], GA[auth P], IA[auth R], S[auth T], U[auth V], W[auth X], Y[auth Z]|Fab 2G1 heavy chain|Homo sapiens (9606) EVQLVESGAEVKKPGSSVKVSCKASGGTFITHVFTWVRQAPGQGLEWVGGFIAIFGTSNYAQKFQGRVTITADESTSTAYMELTSLTSEDTAVYYCARGISGSYGWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC |
Light Chain: S
Mutation: NULL
| >4HG4_S|Chain BA[auth K], DA[auth M], FA[auth O], HA[auth Q], JA[auth S], T[auth U], V[auth W], X[auth Y], Z[auth z]|Fab 2G1 light chain|Homo sapiens (9606) DIQLTQSPSSLSASVGDRVTITCQASQDIRKYLNWYQQKPGKAPNLLIYDASNVKTGVPSRFRGSGSGTDFTFTISSLQPEDIATYYCQQYDNLPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: E
Mutation: NULL
| >4HG4_E|Chain A, C[auth B], E[auth C], G[auth D], I[auth E], K[auth F], M[auth G], O[auth H], Q[auth I]|Hemagglutinin HA1|Influenza A virus (382813) PGDQICIGYHANNSTEKVDTILERNVTVTHAKDILEKTHNGKLCKLNGIPPLELGDCSIAGWLLGNPECDRLLSVPEWSYIMEKENPRDGLCYPGSFNDYEELKYLLSSVKHFEKVKILPKDRWTQHTTTGGSRACAVSGNPSFFRNMVWLTKKGSDYPVAKGSYNNTSGEQMLIIWGVHHPNDETEQRTLYQNVGTYVSVGTSTLNKRSTPEIATRPKVNGLGSRMEFSWTLLDMWDTINFESTGNLIAPEYGFKISKRGSSGIMKTEGTLENCETKCQTPLGAINTTLPFHNVHPLTIGECPRYVKSEKLVLATGLRNVPQIESR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| R: THR28 ILE30 THR31 ALA52 ILE53 PHE54 GLY55 THR56 ASN58 GLU73 ILE96 SER97 GLY98 SER99 S: ARG30 TYR32 ASP50 TYR91 ASP92 E: THR128 GLN129 THR131 THR133 GLY134 GLY135 SER136 ARG137 PRO145 TRP153 THR155 LYS156 LYS157 GLY158 SER159 ASP160 PRO162 ASP187 THR189 GLU190 THR193 LEU194 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
