Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6841 |
| PDBID: | 4HEM |
| Chains: | F_A |
| Organism: | Lactococcus phage TP901-1, Lama glama |
| Method: | XRD |
| Resolution (Å): | 1.65 |
| Reference: | 10.1073/pnas.1301336110 |
| Antibody | |
| Antibody: | anti-TP901-1 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Receptor binding proteins (RBPs) in the phage TP901-1 baseplate |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: F
Mutation: NULL
| >4HEM_F|Chain D[auth E], E[auth F], F[auth G]|Anti-baseplate TP901-1 Llama vHH 02|Lama glama (9844) QVQLVESGGGLVQAGGSLRLSCAASESTFSNYAMGWFRQAPGPEREFVATISQTGSHTYYRNSVKGRFTISRDNAKNTVYLQMNNMKPEDTAVYYCAAGDNYYYTRTYEYDYWGQGTQVTVSS |
Antigen
Chain: A
Mutation: NULL
| >4HEM_A|Chain A, B, C|BPP|Lactococcus phage TP901-1 (35345) MASIKKVYRGMKNGAETINDDLEAINSELTSGGNVVHKTGDETIAGKKTFTGNVEVNGSLTLPTKSWSGELGGGIILSLRKKGTTVEYSIGGEISSSILANSNLVNRSVPNEFCPRNRCSLVGHMVGGWNAFHIDIPSSGVCQWFGPTASSGTPRGTGTYPID |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| F: ASP100 ASN101 TYR103 TYR104 TYR108 GLU109 A: ASN101 ARG116 ASN117 ARG118 SER120 ASP135 SER138 GLN143 PHE145 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
