Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 684 |
| PDBID: | 3V7A |
| Chains: | EH_A |
| Organism: | Mus musculus, Norovirus isolates |
| Method: | XRD |
| Resolution (Å): | 3.30 |
| Reference: | 10.1128/JVI.06868-11 |
| Antibody | |
| Antibody: | 5B18 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Norovirus Capsid |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: E
Mutation: NULL
| >3V7A_E|Chain A[auth E], C[auth F]|5B18 heavy chain|Mus musculus (10090) QVQLQQSGAELVRPGTSVKVSCKASGYAFTNYLIEWVKQRPGQGLEWIGVINPRSGDTNSNEKFKGKAILTADKSSSTAYMQLSSLTSDDSAVYFCARSGTTAYFAMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCT |
Light Chain: H
Mutation: NULL
| >3V7A_H|Chain B[auth G], D[auth H]|5B18 kappa chain|Mus musculus (10090) DIQMTQSPASLSASVGETVTITCRASENIYSYLAWYQQKQGKSPQLLVYNVKTLAEGVPSRFSGSGSGTQFSLKINSLQPEDFGSYYCQHHYGSPPWTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: A
Mutation: NULL
| >3V7A_A|Chain E[auth A], F[auth B]|Capsid|Human calicivirus (150080) SKPFTLPILTLGELTNSRFPLPIDVLYTNPNESAIVQCQNGRCTLDGELQGTTQLLPTGICAFRGKVTQQVQDEHRGTHWNMTVTNLNGTPFDPTEDVPAPLGTPDFSGQIYGVISQRNTNTVPGEGNLPANRAHEAVIATYSPKFTPKLGNIQFSTWETQDVSSGQPTKFTPVGLASVDANSHFDQWTLPSYSGALTLNMNLAPSVAPVFPGECLLFFRSFIPLKGGYGNPAIDCLMPQEWVQHLYQESAPSLSDVALVRYVNPETGRTLFEAKLHRNGFLTVARNSAGPVVAPTNGYFRFDSWVNQFYTLAPM |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| E: ASN31 LEU33 VAL50 ASN52 ARG54 SER55 ASP57 THR58 ASN59 GLY100 THR101 TYR104 PHE105 H: TYR30 SER31 TYR32 HIS91 TYR92 GLY93 SER94 PRO95 TRP97 A: PRO432 VAL433 PHE434 PRO435 GLY436 ARG484 GLU496 ALA508 ASN510 VAL529 ASN530 GLN531 PHE532 TYR533 THR534 LEU535 ALA536 PRO537 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
