Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6839 |
| PDBID: | 4HEM |
| Chains: | E_B |
| Organism: | Lactococcus phage TP901-1, Lama glama |
| Method: | XRD |
| Resolution (Å): | 1.65 |
| Reference: | 10.1073/pnas.1301336110 |
| Antibody | |
| Antibody: | anti-TP901-1 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Receptor binding proteins (RBPs) in the phage TP901-1 baseplate |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: E
Mutation: NULL
| >4HEM_E|Chain D[auth E], E[auth F], F[auth G]|Anti-baseplate TP901-1 Llama vHH 02|Lama glama (9844) QVQLVESGGGLVQAGGSLRLSCAASESTFSNYAMGWFRQAPGPEREFVATISQTGSHTYYRNSVKGRFTISRDNAKNTVYLQMNNMKPEDTAVYYCAAGDNYYYTRTYEYDYWGQGTQVTVSS |
Antigen
Chain: B
Mutation: NULL
| >4HEM_B|Chain A, B, C|BPP|Lactococcus phage TP901-1 (35345) MASIKKVYRGMKNGAETINDDLEAINSELTSGGNVVHKTGDETIAGKKTFTGNVEVNGSLTLPTKSWSGELGGGIILSLRKKGTTVEYSIGGEISSSILANSNLVNRSVPNEFCPRNRCSLVGHMVGGWNAFHIDIPSSGVCQWFGPTASSGTPRGTGTYPID |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| E: PHE47 HIS57 TYR59 ARG61 ASN62 LYS65 TYR102 TYR103 TYR104 THR105 ARG106 GLU109 B: TRP67 SER68 GLY69 GLU70 GLY74 ILE76 SER78 SER89 ILE90 GLY91 GLY92 GLU93 SER95 SER96 VAL126 THR153 ARG155 GLY156 THR157 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
