Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6826 |
| PDBID: | 4GMS |
| Chains: | JN_E |
| Organism: | Influenza A virus (A/Victoria/3/1975(H3N2)), Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.95 |
| Reference: | 10.1073/pnas.1212371109 |
| Antibody | |
| Antibody: | S139/1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin HA1 |
| Antigen mutation: | No |
| Durg Target: | P03437 |
Sequence information
Antibody
Heavy Chain: J
Mutation: NULL
| >4GMS_J|Chain H, J[auth I], L[auth J]|Fab S139/1 heavy chain|Mus musculus (10090) QVQLQQSGTELKKPGASVKISCKATGYTFSSYWIEWIKQRPGHGLEWIGEILPEIGMTNYNENFKGKATFTANTSSNTVYMQLSSLTSEDSAVYYCARPYDYSWFAYWGQGTLVTVSAAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGHHHHHH |
Light Chain: N
Mutation: NULL
| >4GMS_N|Chain G[auth L], I[auth M], K[auth N]|Fab S139/1 light chain|Mus musculus (10090) DIVMTQSQKFMSTSVGDRVSVTCKASQNVDTNVAWYQEKPGQSPKTLIYSASNRYSGVPDRFTGSASGTDFTLTITNVQSEDLAEYFCQQYNSYPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: E
Mutation: NULL
| >4GMS_E|Chain A, C, E|Hemagglutinin HA1 chain|Influenza A virus (392809) GATLCLGHHAVPNGTLVKTITNDQIEVTNATELVQSSSTGKICNNPHRILDGINCTLIDALLGDPHCDGFQNEKWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFINEGFNWTGVTQNGGSSACKRGPDSGFFSRLNWLYKSGSTYPVQNVTMPNNDNSDKLYIWGVHHPSTDKEQTNLYVQASGKVTVSTKRSQQTIIPNVGSRPWVRGLSSRISIYWTIVKPGDILVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIGTCSSECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| N: ASN32 TYR91 ASN92 SER93 TYR94 TYR96 J: SER30 SER31 TYR32 TRP33 GLU53 ILE54 GLY55 MET56 THR57 ASN58 THR68 ASP97 TYR98 SER99 E: TYR98 THR131 GLY134 GLY135 SER136 SER137 ASP144 SER145 TRP153 TYR155 LYS156 SER157 GLY158 SER159 THR160 SER186 LYS189 GLU190 THR192 ASN193 LEU194 VAL196 GLY225 LEU226 SER227 SER228 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
