Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6819 |
| PDBID: | 4FQI |
| Chains: | HL_B |
| Organism: | Influenza A virus (A/Viet Nam/1203/2004(H5N1)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.71 |
| Reference: | 10.1126/science.1222908 |
| Antibody | |
| Antibody: | CR9114 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H5N1 hemagglutinin HA2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4FQI_H|Chain C[auth H]|antibody CR9114 heavy chain|Homo sapiens (9606) QVQLVQSGAEVKKPGSSVKVSCKSSGGTSNNYAISWVRQAPGQGLDWMGGISPIFGSTAYAQKFQGRVTISADIFSNTAYMELNSLTSEDTAVYFCARHGNYYYYSGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCHHHHHH |
Light Chain: L
Mutation: NULL
| >4FQI_L|Chain D[auth L]|antibody CR9114 light chain|Homo sapiens (9606) QSALTQPPAVSGTPGQRVTISCSGSDSNIGRRSVNWYQQFPGTAPKLLIYSNDQRPSVVPDRFSGSKSGTSASLAISGLQSEDEAEYYCAAWDDSLKGAVFGGGTQLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: B
Mutation: NULL
| >4FQI_B|Chain B|Hemagglutinin HA2|Influenza A virus (284218) GLFGAIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLERRIENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHKCDNECMESVRNGTYDYPQYSEEARLKREEISSGR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR28 ASN30 ASN31 TYR32 ILE53 PHE54 SER56 ILE73 PHE74 ASN97 TYR98 TYR99 L: ARG31 B: VAL18 ASP19 GLY20 TRP21 LYS38 THR41 GLN42 ILE45 ASP46 VAL48 THR49 VAL52 ASN53 ILE56 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
