Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6814 |
| PDBID: | 4FFZ |
| Chains: | ZY_X |
| Organism: | Dengue virus 1 Nauru/West Pac/1974, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 3.80 |
| Reference: | 10.1371/journal.ppat.1002930 |
| Antibody | |
| Antibody: | DENV1-E111 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Dengue virus (DENV) type 1 envelope glycoprotein domain III |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: Z
Mutation: NULL
| >4FFZ_Z|Chain C[auth H], F[auth Z]|DENV1-E111 fab fragment (heavy chain)|Mus musculus (10090) QVQLLQPGAELVKPGASMKLSCKASGYTFTNWWMHWVRLRPGRGLEWIGRIDPNSDVNKYNEKFENRASLTVDKHSSTAYMQLSSLTSEDSAIYYCARWFFPWYFDVWGTGTTVTVSSAKTTAPSVYPLAPVCGGTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPALLQSGLYTLSSSVTVTSNTWPSQTITCNVAHPASSTKVDKKIES |
Light Chain: Y
Mutation: NULL
| >4FFZ_Y|Chain B[auth L], E[auth Y]|DENV1-E111 fab fragment (light chain)|Mus musculus (10090) NIVLTQSPASLAVSLGQRATISCRASESVDHYGNSFIYWYQQKPGQPPKLLIYLASNLESGVPARFSGSGSETDFTLTIDSVETDDAATYYCQQNNEDPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRN |
Antigen
Chain: X
Mutation: NULL
| >4FFZ_X|Chain A, D[auth X]|Envelope protein E|Dengue virus 1 (11059) MASMTLKGMSYVMCTGSFKLEKEVAETQHGTVLVQVKYEGTDAPCKIPFSSQDEKGVTQNGRLITANPIVTDKEKPVNIEAEPPFGESYIVVGAGEKALKLSWFKKGSSIG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Y: ASN30 PHE32 TYR49 LEU50 ASN53 ASN91 ASN92 GLU93 ASP94 TYR96 Z: ASN31 TRP32 TRP33 ARG50 VAL56 ASN57 LYS58 TRP95 PHE96 PHE97 PRO98 TRP99 X: TYR299 VAL300 MET301 LYS334 ILE335 PRO336 PHE337 SER338 SER339 GLN340 GLU342 LYS343 GLY344 VAL345 THR346 GLN347 ASN348 GLY349 ARG350 LEU351 ASN355 ALA369 GLU370 PRO371 VAL379 GLY381 ALA382 GLY383 GLU384 LYS385 ALA386 LYS388 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
